The Curious Link Between Estrogen, Mast Cells, and Histamine

The role of mast cells and histamine in estrogen dominanceHeadaches, anxiety, insomnia, brain fog, hives, and nasal congestion. These are just a few of the symptoms of mast cell activation or high histamine.

Histamine symptoms are more common in women and often track with the menstrual cycle, occurring when estrogen is high at ovulation and then again just before the period. 

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Why I Don’t Use the Term Estrogen Dominance

Estrogen dominance is not a medical term.

Estrogen dominance means high estrogen compared to progesterone. It’s a real condition and, at the same time, a not-very-helpful term.

There are better ways to discuss estrogen and progesterone balance.

First, it’s normal to have no progesterone during the follicular phase, which is the first two to three weeks of the menstrual cycle.

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