High-dose fructose can cause or worsen insulin resistance, abdominal weight gain, fatty liver, heavy periods, and PCOS.
High-dose fructose comes from table sugar (sucrose), high-fructose corn syrup, and even some natural sweeteners such as agave, coconut sugar, dates, dried fruit, and fruit juice.
Whole fruit is healthy and does not cause insulin resistance because 1) whole fruit contains only low-dose fructose, and 2) fruit also provides beneficial nutrients, fibre, and polyphenols.