The Role of Histamine and Mast Cells in PMS and PMDD

histamine and PMDD

Mast cell activation and histamine can play a role in premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). 

That’s why mid-cycle, premenstrual, and perimenopausal mood symptoms can be relieved by antihistamines and natural histamine-reducing strategies such as vitamin B6, SAM-e, and a dairy-free diet. 

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Why Progesterone Is Both Good and Bad for Mood (and How to Treat PMDD)

Mood effects of progesterone.Progesterone is usually soothing to mood but can sometimes cause anxiety. A negative mood reaction to progesterone is called neurosteroid change sensitivity or premenstrual dysphoric disorder (PMDD) and affects about one in twenty women.

Here’s everything you need to know about progesterone and mood.

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The Dos and Don’ts of Vitex for Period Problems

Vitex or chastetree for period problems.Vitex (also called chaste tree or chasteberry) is a herbal medicine prepared from the berries of the Mediterranean tree Vitex agnus-castus. In ancient times, it was used to suppress the libido of monks, hence the name. Fortunately, it does not have that effect on women.

Vitex is effective medicine for breast pain, irregular periods, premenstrual mood symptoms, and some types of acne.

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Why I Prescribe Iodine for Breast Pain, Ovarian Cysts, and PMDD

Iodine for female hormones.

As I discuss in my new book Hormone Repair Manual, iodine helps with breast pain, premenstrual mood symptoms, and the prevention of ovarian cysts. It works by promoting healthy estrogen metabolism, down-regulating estrogen receptors, and stabilising estrogen-sensitive tissue including breasts, uterus, ovaries, and the brain.

Iodine’s anti-estrogen effect makes it one of the best treatments for estrogen excess or “estrogen dominance,” although I don’t use that term.

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