Puffy eyes taking Prometrium

[Breas_au]

I've been taking Prometrium for perimenopause symptoms. I've been taking the dose recommended of 300mg per night, for about 5 nights now. However, in that time I've noticed my eyes have been very puffy everyday and don't go down. Has anyone else noticed this?

[Jeslyn]

That wouldn't be a common side-effect for Prometrium, but it can cause fluid-retention, which I guess could come in the form of puffiness around the eyes. Are they itchy as well? If they are, then I suspect it's something else and the timing is just coincidence.

You could always stop the Prometrium for a few days. If the puffiness goes away, then maybe it's the Prometrium. At that point, you'd start taking it again, and if the puffiness comes back, it seems like a strong connection.

Probably something you should discuss with your healthcare provider anyway.